The plant Flacourtia sepiaria has numerous therapeutic utility in folk medicine. So the plant has been selected to investigate the anti-arthritic and anticancer activities of various extracts.The anti-arthritic as well as anti-cancer activities of various extracts of aerial parts of Flacourtia sepiaria was examined by protein denaturation inhibition method, membrane stabilization method and MTT calorimetric assay in HeLa and MCF-7 cell lines respectively.The inhibition of protein denaturation and membrane stabilization was highest in methanolic extract and lowest in petroleum ether extract. The anti-arthritic activities of methanolic extract was significant (p<0.05) when compared with standard diclofenac. The maximum percentage inhibition of protein denaturation and membrane stabilization of methanolic extract was found to be 80.37�±1.34 and 78.57�±1.39 at a dose of 1000 �µg/ml respectively. The MTT assay showed that the methanolic extract has moderate cytotoxicity against the cell lines. The result shows that the Flacoutia sepiaria exhibited anti-arthritic and anti-cancer activity.
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